Klimis-Tavantzis D J, Leach R M, Kris-Etherton P M
J Nutr. 1983 Feb;113(2):328-36. doi: 10.1093/jn/113.2.328.
Two experiments were conducted to determine the effect of dietary manganese on cholesterol and lipid metabolism in the Wistar rat and the genetically hypercholesterolemic RICO rat. Weanling animals were placed on a manganese-deficient (0.12 microgram/g) and a supplemented diet (100.12 micrograms/g). Mean body weights, hepatic fatty acid synthesis and liver manganese concentration significantly decreased in the deficient group of Wistar rats. Plasma cholesterol, VLDL (very low density lipoprotein) and HDL (high-density lipoprotein) cholesterol, hepatic cholesterol synthesis, liver cholesterol and lipid concentrations were not significantly affected by manganese deficiency. Mean body weights and hepatic manganese content were lower in the manganese-deficient group in both normal and hypercholesterolemic RICO rats. Manganese deficiency significantly decreased LDL cholesterol concentration in the hypercholesterolemic RICO rats. Manganese deficiency had no significant effect on hepatic cholesterol and fatty acid synthesis, plasma cholesterol, VLDL and HDL cholesterol concentrations, liver lipid and liver cholesterol concentration in either group of RICO rats. These results indicate that dietary manganese deficiency does not result in significant alterations in cholesterol and lipid metabolism in the rat.
进行了两项实验，以确定日粮锰对Wistar大鼠和遗传性高胆固醇血症RICO大鼠胆固醇及脂质代谢的影响。将断奶动物分为缺锰组（0.12微克/克）和补锰组（100.12微克/克）。Wistar大鼠缺锰组的平均体重、肝脏脂肪酸合成及肝脏锰浓度显著降低。缺锰对血浆胆固醇、极低密度脂蛋白（VLDL）和高密度脂蛋白（HDL）胆固醇、肝脏胆固醇合成、肝脏胆固醇及脂质浓度无显著影响。正常和高胆固醇血症RICO大鼠的缺锰组平均体重和肝脏锰含量均较低。缺锰显著降低了高胆固醇血症RICO大鼠的低密度脂蛋白胆固醇浓度。缺锰对两组RICO大鼠的肝脏胆固醇和脂肪酸合成、血浆胆固醇、VLDL和HDL胆固醇浓度、肝脏脂质及肝脏胆固醇浓度均无显著影响。这些结果表明，日粮缺锰不会导致大鼠胆固醇及脂质代谢发生显著改变。
