Burns R J, Bar-Shlomo B Z, Druck M N, Herman J G, Gilbert B W, Perrault D J, McLaughlin P R
Am J Med. 1983 Feb;74(2):297-302. doi: 10.1016/0002-9343(83)90631-9.
Twenty-one asymptomatic adults underwent rest and exercise gated radionuclide angiography seven to 20 years after having received mediastinal radiation (2,000 to 7,600 rads) for Hodgkin's disease. None of these patients received cytotoxic chemotherapy. Twelve patients (57 percent) had abnormal left (less than 53 percent at rest and/or greater than 5 percent decrease at peak exercise) and/or right (less than 27 percent at rest and/or greater than 5 percent decrease at peak exercise) ventricular ejection fractions. Previous reports have described myocardial fibrosis occurring late after therapeutic mediastinal radiation; however, the incidence of this occurrence based on clinical follow-up has been low. Rest and exercise radionuclide angiography is a sensitive method for assessing systolic ventricular function and reveals a high prevalence of cardiomyopathy that can be linked to previous radiotherapy.
21名无症状成年人在接受纵隔放疗（2000至7600拉德）治疗霍奇金病7至20年后，进行了静息和运动门控放射性核素血管造影。这些患者均未接受细胞毒性化疗。12名患者（57%）左心室射血分数异常（静息时低于53%和/或运动高峰时下降超过5%）和/或右心室射血分数异常（静息时低于27%和/或运动高峰时下降超过5%）。先前的报告描述了治疗性纵隔放疗后晚期发生的心肌纤维化；然而，基于临床随访的这种情况的发生率一直很低。静息和运动放射性核素血管造影是评估心室收缩功能的一种敏感方法，并且显示出与先前放疗相关的心肌病的高患病率。
