Shanahan E C, Marshall A G, Garrett C P
Anaesthesia. 1983 Jan;38(1):40-3. doi: 10.1111/j.1365-2044.1983.tb10371.x.
Adverse reactions ranging from tachycardia and cutaneous vasodilatation to severe hypotension and apnoea occurred in three children who were given codeine phosphate intravenously. The cause of these reactions is discussed and a review of the literature on the parenteral use of codeine phosphate is presented. The findings indicate that the standard reference formularies and pharmacopeoiae, with one exception, deal inadequately with the parenteral use of codeine phosphate. On the evidence of the cases presented we would support the conclusion of the American Medical Association's drug evaluations, that codeine phosphate should not be used intravenously in children.
三名静脉注射磷酸可待因的儿童出现了不良反应，从心动过速和皮肤血管扩张到严重低血压和呼吸暂停。本文讨论了这些反应的原因，并对磷酸可待因肠胃外使用的文献进行了综述。研究结果表明，除了一个例外，标准参考处方集和药典对磷酸可待因肠胃外使用的处理都不充分。根据所呈现病例的证据，我们支持美国医学协会药物评估的结论，即磷酸可待因不应在儿童中静脉使用。
