Persson K, Sjöström S, Sigurdardottir I, Molnár V, Hammarlund-Udenaes M, Rane A
Department of Clinical Pharmacology, Akademiska Hospital, Uppsala, Sweden.
Br J Clin Pharmacol. 1995 Feb;39(2):182-6. doi: 10.1111/j.1365-2125.1995.tb04428.x.
Postoperative pain relief with codeine was evaluated in 11 women undergoing hysterectomy. Patient-controlled analgesia (PCA) was used to administer codeine. After the study the patients were phenotyped with respect to the O-demethylation of dextromethorphan (cytochrome P4502D6 polymorphism). Ten were extensive metabolisers and one a poor metaboliser. There was a nine-fold variation in the minimum plasma concentration of codeine consistent with pain relief (40-350 ng ml-1). Two patients did not experience any effect of codeine, one of whom was a poor metaboliser of dextromethorphan, confirmed by genotyping. In the other nine patients the effective dose of codeine varied from 4.8-25.3 mg h-1.
对11名接受子宫切除术的女性患者使用可待因进行术后镇痛效果评估。采用患者自控镇痛（PCA）方式给予可待因。研究结束后，根据右美沙芬O-去甲基化情况（细胞色素P4502D6多态性）对患者进行表型分析。其中10人为快代谢型，1人为慢代谢型。可待因达到疼痛缓解效果时的最低血浆浓度存在9倍差异（40 - 350 ng/ml）。两名患者未出现可待因的任何效果，其中一名经基因分型证实为右美沙芬慢代谢型。在其他9名患者中，可待因的有效剂量为4.8 - 25.3 mg/h。
