Greenspon A J, Schaal S F
Ann Intern Med. 1983 Feb;98(2):135-9. doi: 10.7326/0003-4819-98-2-135.
Although the "holiday heart syndrome," highlighted by rhythm disturbances after acute alcohol ingestion, is well known, the potential arrhythmogenic effects of alcohol have not been studied. Fourteen patients (two with congestive cardiomyopathy) with a history of rhythm disturbances and alcohol consumption were studied electrophysiologically. One patient had nonsustained ventricular tachycardia, one had nonsustained atrial fibrillation, one had paired ventricular responses, and the remainder had no response to the extrastimulus technique. After 90 mL of 80-proof whiskey, 10 of the 14 patients developed sustained or nonsustained atrial or ventricular tachyarrhythmias. Significant prolongation of His-ventricular conduction was seen after alcohol intake; this was noteworthy as one of the patients had previously shown Mobitz II atrioventricular block after acute alcohol consumption. Alcohol in modest doses has the potential to produce rhythm disturbances in patients with a history of chronic alcohol consumption and heart disease.
尽管急性酒精摄入后出现的心律失常所凸显的“假日心脏综合征”广为人知，但酒精潜在的致心律失常作用尚未得到研究。对14例有心律失常病史且饮酒的患者（其中2例患有充血性心肌病）进行了电生理研究。1例患者有非持续性室性心动过速，1例有非持续性心房颤动，1例有配对室性反应，其余患者对额外刺激技术无反应。在饮用90毫升80度威士忌后，14例患者中有10例出现持续性或非持续性房性或室性快速心律失常。饮酒后可见希氏束-心室传导显著延长；值得注意的是，其中1例患者此前在急性酒精摄入后曾出现莫氏Ⅱ型房室传导阻滞。适度剂量的酒精有可能在有慢性饮酒史和心脏病史的患者中产生心律失常。
