Watanabe K, Watanabe I
Ann Otol Rhinol Laryngol. 1983 Jan-Feb;92(1 Pt 1):70-4. doi: 10.1177/000348948309200117.
The fine structure of human nasal blood vessels was studied in 15 nasal allergic patients. Biopsies were taken at different stages after provocation. In the early stage (two minutes after provocation), characteristic alterations of capillaries and venules were congestion, gap formation between two endothelial cells, and swollen vascular endothelial cells. Evidence of locally increased vascular permeability and congestion causing mucosal edema was found. In the late stage (20 minutes after provocation), evidence of congestion disappeared. Vascular dilatation and marked interendothelial cell gaps were observed. In both perivascular space and sometimes in intravascular space, degranulated eosinophils were observed, suggesting that not only histamine but also lysosomal enzymes in eosinphil granules may be involved in causing increased vascular permeability.
对15名鼻过敏患者的人类鼻血管精细结构进行了研究。在激发后的不同阶段进行活检。在早期阶段（激发后两分钟），毛细血管和小静脉的特征性改变为充血、两个内皮细胞之间形成间隙以及血管内皮细胞肿胀。发现了局部血管通透性增加和充血导致粘膜水肿的证据。在晚期阶段（激发后20分钟），充血证据消失。观察到血管扩张和明显的内皮细胞间隙。在血管周围间隙以及有时在血管内间隙中，观察到了脱颗粒的嗜酸性粒细胞，这表明不仅组胺，而且嗜酸性粒细胞颗粒中的溶酶体酶可能也参与了导致血管通透性增加的过程。
