Konno A, Numata T, Terada N, Hanazawa T, Nagata H, Motosugi H
Department of Otorhinolaryngology, Chiba University School of Medicine, Japan.
Ann Otol Rhinol Laryngol. 1996 Aug;105(8):648-53. doi: 10.1177/000348949610500811.
The effects of topically administered substance P (SP) on nasal blood flow and nasal airway resistance (NAR) were evaluated in 11 subjects with perennial nasal allergy. The change in NAR induced by SP was compared with those induced by nasal challenge with histamine, leukotriene D4 (LTD4), and antigen. In doses > or = 16 nmol, SP caused a significant increase of nasal blood flow within 5 minutes that lasted for less than 20 minutes. In doses > or = 16 nmol, SP caused a dose-dependent, short-lasting, significant increase in NAR. The magnitude of the increase in NAR was LTD4 > SP > histamine when compared on a molar basis. Our results may suggest that SP released from C fiber terminals is partially involved in an early nasal vascular response after antigen challenge by acting on adjacent vascular smooth muscle to cause a transient vasodilatation of both resistance and capacitance vessels only while sensory stimulation persists in subjects with nasal allergy.
对11名常年性鼻过敏患者评估了局部应用P物质（SP）对鼻血流和鼻气道阻力（NAR）的影响。将SP诱导的NAR变化与组胺、白三烯D4（LTD4）和抗原进行鼻激发试验诱导的变化进行比较。剂量≥16 nmol时，SP在5分钟内引起鼻血流显著增加，持续时间不到20分钟。剂量≥16 nmol时，SP引起NAR剂量依赖性、短暂性显著增加。以摩尔为基础比较时，NAR增加的幅度为LTD4＞SP＞组胺。我们的结果可能表明，在鼻过敏患者中，仅当感觉刺激持续时，C纤维终末释放的SP通过作用于相邻血管平滑肌，使阻力血管和容量血管短暂扩张，从而部分参与抗原激发后的早期鼻血管反应。
