Lanser M E, Saba T M
Arch Surg. 1983 Mar;118(3):338-42. doi: 10.1001/archsurg.1983.01390030070011.
Opsonic fibronectin modulates reticuloendothelial (RE) uptake of nonbacterial particulates, as well as some bacterial strains, and may thus play an important role in host defense against sepsis after burn injury. We evaluated the relationship between burn injury, sepsis, and opsonic fibronectin levels in rats, as well as the ability to reverse the acute opsonic deficiency after burn injury by administration of purified opsonic fibronectin. Burn injury resulted in an acute (within one hour) depletion of opsonic fibronectin (from 341 +/- 30 to 98 +/- 7 mg/L) that was correctable by administration of purified opsonic fibronectin when accompanied by moderate sepsis, while burn injury plus severe sepsis (level, 168 +/- 30 mg/L) limited attempted restoration of normal opsonic levels (level, 121 +/- 18 mg/L). The in vitro serum opsonic deficit was partially correctable (from 2.2% to 6.7% of the injected dose per 100 mg), while in vivo RE functional deficits could not be corrected. We conclude that the acute postburn deficiency in opsonic fibronectin is amenable to repletion therapy; however, many additional factors may contribute to acute RE failure after burn injury.
调理素纤连蛋白可调节网状内皮系统（RE）对非细菌性颗粒以及某些细菌菌株的摄取，因此可能在烧伤后宿主抵御败血症的防御中发挥重要作用。我们评估了大鼠烧伤、败血症与调理素纤连蛋白水平之间的关系，以及通过给予纯化的调理素纤连蛋白来逆转烧伤后急性调理素缺乏的能力。烧伤导致调理素纤连蛋白急性（1小时内）耗竭（从341±30降至98±7mg/L），在伴有中度败血症时，给予纯化的调理素纤连蛋白可纠正这种情况，而烧伤加严重败血症（水平为168±30mg/L）则限制了恢复正常调理素水平（水平为121±18mg/L）的尝试。体外血清调理素缺乏可部分纠正（从每100mg注射剂量的2.2%升至6.7%），而体内RE功能缺陷无法纠正。我们得出结论，烧伤后急性调理素纤连蛋白缺乏适合进行补充治疗；然而，许多其他因素可能导致烧伤后急性RE功能衰竭。
