Hedges T R, Jones A, Stark L, Hoyt W F
Arch Ophthalmol. 1983 Feb;101(2):211-3. doi: 10.1001/archopht.1983.01040010213005.
Two patients with botulin ophthalmoplegia had rapid quivering eye motions during attempts to refixate laterally placed objects; these abnormal eye movements occurred in conjunction with a disjunctive limitation of range of eye movements. Oculographic examination showed that the quivering motions were composed of multiple hypometric saccades, many of which had subnormal and stuttering velocities. By blocking acetylcholine release into myoneural junctions, botulin toxin seems to limit the duration of saccadic burst innervation reaching ocular muscle.
两名肉毒杆菌性眼肌麻痹患者在试图重新注视侧向放置的物体时出现快速眼球颤动；这些异常眼动与眼球运动范围的分离性受限同时出现。眼动图检查显示，颤动运动由多个幅度不足的扫视组成，其中许多扫视速度低于正常且有卡顿。通过阻断乙酰胆碱释放到肌神经接头，肉毒杆菌毒素似乎限制了到达眼肌的扫视爆发性神经支配的持续时间。
