Harrington T M, Cohen M D, Bartleson J D, Ginsburg W W
Arthritis Rheum. 1983 Feb;26(2):201-5. doi: 10.1002/art.1780260212.
Serum creatine kinase (CK) levels were recorded in 100 patients with amyotrophic lateral sclerosis (ALS). CK concentrations were elevated in 43% of the patients, with a mean level of 240 U/liter and a range of 59-1,327 U/liter (male normal less than 95 U/liter, female normal less than 59 U/liter). All patients with elevated CK had muscle weakness. Seven patients were initially misdiagnosed as having polymyositis and given high dose corticosteroids without clinical benefit, prior to the diagnosis of ALS. Such diagnostic confusion can be avoided by an awareness that CK levels cannot be used to reliably differentiate between ALS and primary muscle disease such as polymyositis.
对100例肌萎缩侧索硬化症（ALS）患者的血清肌酸激酶（CK）水平进行了记录。43%的患者CK浓度升高，平均水平为240 U/升，范围为59 - 1327 U/升（男性正常水平低于95 U/升，女性正常水平低于59 U/升）。所有CK升高的患者均有肌肉无力症状。7例患者最初被误诊为多发性肌炎，并在诊断为ALS之前接受了高剂量皮质类固醇治疗，但无临床益处。认识到CK水平不能可靠地区分ALS和原发性肌肉疾病（如多发性肌炎），可以避免这种诊断混淆。
