Stephan F K
Behav Brain Res. 1983 Jan;7(1):81-98. doi: 10.1016/0166-4328(83)90006-2.
Rats with lesions of the suprachiasmatic nucleus (SCN) were maintained in constant darkness and placed on restricted feeding schedules with 1 h access to food twice per day. When both schedules had a 24 h period and food access was spaced 12 h apart, all rats with SCN lesions displayed anticipatory activity to both feedings. In the first experiment, the period of one schedule was then changed to 25 h while the other continued with a period of 24 h. None of the rats with SCN lesions were able to anticipate both schedules simultaneously. In a second experiment, 24 h and 24.5 h schedules were used. Five of 6 rats with SCN lesions anticipated both schedules for at least 9 days and 2 of these anticipated both schedules for 48 days. This forced dissociation of activity into two components with different periods is consistent with the hypothesis that entrainment of activity by restricted food access is mediated by more than one circadian pacemaker.
对视交叉上核（SCN）受损的大鼠持续置于黑暗环境中，并采用限时进食计划，即每天有1小时的进食时间，分两次进行。当两个进食计划的周期均为24小时且进食时间间隔为12小时时，所有视交叉上核受损的大鼠对两次进食均表现出预期活动。在第一个实验中，将其中一个进食计划的周期改为25小时，而另一个仍保持24小时的周期。没有一只视交叉上核受损的大鼠能够同时预期两个进食计划。在第二个实验中，采用了24小时和24.5小时的进食计划。6只视交叉上核受损的大鼠中有5只至少在9天内预期了两个进食计划，其中2只在48天内都预期了两个进食计划。这种将活动强行分离为两个不同周期成分的现象与以下假设一致，即限时进食对活动的调节是由多个昼夜节律起搏器介导的。
