Xu C F
Nanjing Medical College.
Zhonghua Fu Chan Ke Za Zhi. 1993 Aug;28(8):496-7, 508.
The study of the SCE frequencies and chromosome aberrations in 20 patients with cervical carcinoma and 20 cases of healthy women was carried out. The result showed that the SCE frequencies were as high as 9.28 +/- 0.34/cell in the patients with cervical cancer. They were significantly higher than those of the normal control group (P < 0.001). The chromosomal numerical changes and structural aberrations of the patients were much more than those of the normal women (P < 0.01). The important structural aberrations included ring chromosome, chromosomal restituation and breakage. Genetic instability and DNA repair level significantly suppressed in cancer patients were detected.
对20例宫颈癌患者和20例健康女性进行了姐妹染色单体交换（SCE）频率和染色体畸变的研究。结果显示，宫颈癌患者的SCE频率高达9.28±0.34/细胞。它们显著高于正常对照组（P<0.001）。患者的染色体数目变化和结构畸变比正常女性多得多（P<0.01）。重要的结构畸变包括环状染色体、染色体重建和断裂。检测到癌症患者的遗传不稳定性和DNA修复水平明显受到抑制。
