Nomoto K, Shimamoto Y, Taniguchi K, Kubo C, Kawauchi H, Mitsuyama M, Takeya K
Cell Immunol. 1983 Jan;75(1):134-43. doi: 10.1016/0008-8749(83)90312-x.
The thymus requirement for the development of immunological responsiveness was determined by estimation of immune responses raised to Listeria monocytogenes in athymic nude, neonatally thymectomized, and sham-operated mice at 6 weeks of age. Not only sham-operated mice, but also neonatally thymectomized mice could completely eliminate the bacteria from the spleen and liver, while athymic nude mice could not eliminate them and showed a persistent form of infection. A strong delayed footpad reaction and acquired cellular resistance could be raised in neonatally thymectomized mice just as well as in sham-operated mice, but not in athymic nude mice. The delayed footpad reaction could be induced in neonatally thymectomized mice without an accompanying ability to inhibit macrophage migration. These results suggest that T cells responsible for immunity against listerial infection require the presence of the thymus for only a very short period in their development.
通过评估6周龄的无胸腺裸鼠、新生期胸腺切除小鼠和假手术小鼠对单核细胞增生李斯特菌产生的免疫反应，确定胸腺对免疫反应性发育的需求。不仅假手术小鼠，新生期胸腺切除小鼠也能完全清除脾脏和肝脏中的细菌，而无胸腺裸鼠则无法清除，呈现持续性感染。新生期胸腺切除小鼠与假手术小鼠一样，能够产生强烈的足垫迟发型反应和获得性细胞抗性，但无胸腺裸鼠则不能。新生期胸腺切除小鼠可诱导出足垫迟发型反应，但其不具备抑制巨噬细胞迁移的能力。这些结果表明，负责抗李斯特菌感染免疫的T细胞在其发育过程中仅在很短的时期需要胸腺的存在。
