Abrams J S, Anton J R, Dreyfuss D C
Dis Colon Rectum. 1983 Mar;26(3):141-4. doi: 10.1007/BF02560154.
Reports of an increased incidence of right-sided colonic cancers have coincided with an expanding knowledge of the carcinogenic potential of secondary bile acids which are increased after cholecystectomy, suggesting a possible relationship between cholecystectomy and the subsequent occurrence of proximal colonic cancer. The hospital records of 582 patients undergoing resection of colorectal cancers were reviewed. Fifty-four patients (9 per cent) had had prior cholecystectomies. The distribution of colonic cancers in these patients was identical to that in noncholecystectomized patients. To obtain a prospective view, 249 patients undergoing cholecystectomy between 1958 and 1960 were followed up to 1980. A cancer of the sigmoid colon or rectum occurred in four patients, three to 22 years after cholecystectomy. No patient was readmitted with a carcinoma of the proximal colon. These data fail to support a relationship between cholecystectomy and the subsequent development of a cancer of the cecum or ascending colon.
关于右侧结肠癌发病率增加的报道，恰好与人们对胆囊切除术后次级胆汁酸致癌潜力的认识不断扩展相吻合，这表明胆囊切除术与随后近端结肠癌的发生之间可能存在关联。对582例接受结直肠癌切除术患者的医院记录进行了回顾。54例患者（9%）曾接受过胆囊切除术。这些患者结肠癌的分布与未接受胆囊切除术患者的分布相同。为了获得前瞻性观点，对1958年至1960年间接受胆囊切除术的249例患者进行随访至1980年。4例患者在胆囊切除术后3至22年发生了乙状结肠癌或直肠癌。没有患者因近端结肠癌再次入院。这些数据不支持胆囊切除术与随后盲肠或升结肠癌的发生之间存在关联。
