Carter B L, Reinders T P, Hamilton R A
Drug Intell Clin Pharm. 1983 Jan;17(1):23-6. doi: 10.1177/106002808301700104.
This study was conducted to determine the reliability of two methods of predicting maintenance warfarin dosage. Fifty-nine patients were studied using Method 1 and 44 using Method 2. Both methods produced a statistically significant correlation between predicted and actual dose for the two populations. However, actual vs. predicted doses for individual patients were significantly different. Method 1 predicted a dose within +/- 2.5 mg/d of actual dose in only 40.7 percent of patients. With Method 2, the corresponding value was 56.8 percent. Although the linear regression was statistically significant in our population, many patients would have excessive or subtherapeutic dosage predictions.
本研究旨在确定两种预测华法林维持剂量方法的可靠性。采用方法1对59名患者进行了研究，采用方法2对44名患者进行了研究。两种方法在这两组人群中均得出预测剂量与实际剂量之间具有统计学意义的相关性。然而，个体患者的实际剂量与预测剂量存在显著差异。方法1仅在40.7%的患者中预测出实际剂量±2.5mg/d范围内的剂量。对于方法2，相应的值为56.8%。尽管在我们的研究人群中线性回归具有统计学意义，但许多患者会得到过高或过低的剂量预测。
