D'Arcy P F
Drug Intell Clin Pharm. 1983 Feb;17(2):105-9. doi: 10.1177/106002808301700204.
Letters in correspondence columns or brief reports in medical journals are an essential part of an early warning system, and they are invaluable in alerting clinicians and clinical pharmacists to associations between drugs and their reactions. A survey of the literature during the first half of 1982 has identified a number of these early reports; some are purely anecdotal, others may be coincidental, but all serve to warn the practitioner of potential hazard. Brief information on the following reports of drug-drug interactions is given in this article with the intention of giving these reports wider publicity and, possibly, encouraging further observation and research to establish or disprove their validity in a larger and wider range of patients or volunteer subjects. The following interactions are reviewed: amiodarone-quinidine, lidocaine-prenylamine, erythromycin-carbamazepine, azapropazone-phenytoin, chlordiazepoxide-levodopa, gentamicin-furosemide, ethanol-aspirin, acetaminophen-coumarin anticoagulant, and cimetidine-lidocaine.
医学期刊通信栏目的信件或简短报告是早期预警系统的重要组成部分，对于提醒临床医生和临床药剂师注意药物及其反应之间的关联非常宝贵。一项对1982年上半年文献的调查发现了一些这类早期报告；有些纯粹是轶事性的，其他的可能是巧合，但所有这些都有助于提醒从业者潜在的危害。本文给出了以下药物相互作用报告的简要信息，目的是让这些报告得到更广泛的宣传，并可能鼓励进一步的观察和研究，以在更多更广的患者或志愿者中确定或否定它们的有效性。以下相互作用将进行综述：胺碘酮-奎尼丁、利多卡因-普尼拉明、红霉素-卡马西平、阿扎丙宗-苯妥英、氯氮卓-左旋多巴、庆大霉素-速尿、乙醇-阿司匹林、对乙酰氨基酚-香豆素抗凝剂以及西咪替丁-利多卡因。
