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[咪唑和吡唑二甲酸二酰胺衍生物对糖酵解指标的影响及其结构特征]

[Effect of diamide derivatives of imidazole- and pyrazoledicarboxylic acids on glyolysis indices depending on their structural characteristics].

作者信息

Brovtsyna N B, Bogoslovskaia S I, Borodkin Iu S, Khromov-Borisov N V

出版信息

Farmakol Toksikol. 1983 Jan-Feb;46(1):70-5.

PMID:6825824
Abstract

A study was made of the effect of diamide derivatives of imidazole- and pyrazole-dicarboxylic acids on blood glycolysis in rabbits depending on structural and conformational features of the molecules. It was shown that glycolysis is affected by the position and magnitude of an alkyl substituent in the heterocyclic part of the molecule. An essential role in the manifestation of metabolic activity is played by structural similarity of the test compounds to the adenine molecule.

摘要

研究了咪唑和吡唑二羧酸的二酰胺衍生物对家兔血液糖酵解的影响,该影响取决于分子的结构和构象特征。结果表明,糖酵解受分子杂环部分烷基取代基的位置和大小影响。受试化合物与腺嘌呤分子的结构相似性在代谢活性表现中起重要作用。

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