Bogoslovskaia S I, Brovtsyna N V, Khromov-Borisov N V, Borodkin Iu S
Farmakol Toksikol. 1980 Nov-Dec;43(6):667-71.
It has been ascertained that alkyl derivatives of imidazoledicarboxylic acid diamides produce different effect on respiration and acid-base balance (ABB) of animal body. Antiphein and ethymisole stimulate respiration and change ABB. Ethirazol does not affect respiration, producing only insignificant changes in the respiratory component of ABB. Differences in the biological activity of the test drugs may be related to the structure or position of the alkyl radical in the heterocyclic ring.
已确定咪唑二甲酸二酰胺的烷基衍生物对动物机体的呼吸和酸碱平衡（ABB）产生不同影响。安替非尼和乙噻米唑刺激呼吸并改变酸碱平衡。埃替唑不影响呼吸，仅在酸碱平衡的呼吸成分上产生微小变化。受试药物生物活性的差异可能与杂环中烷基的结构或位置有关。
