Kascsak R J, Carp R I, Donnenfeld H, Bartfeld H
Intervirology. 1983;19(1):6-15. doi: 10.1159/000149331.
The kinetics of replication of lactate dehydrogenase-elevating virus (LDV) in age-dependent polioencephalomyelitis was studied in genetically susceptible (C58/J) and resistant (C57BL/6J) mice. The peripheral replication pattern (plasma concentration) for LDV was similar in both strains. However, the concentration of virus within the central nervous system was strikingly different. In nonsusceptible C57BL/6J mice, little or no virus was found within the central nervous system. In the lumbar cord of susceptible C58/J mice, an increase in the concentration of LDV began 5 days postinfection and continued during the preclinical stages of disease. A direct correlation was shown between the concentration of LDV in spinal cord and the appearance of motor neuron disease but not the degree of inflammatory reaction.
在年龄依赖性脊髓灰质炎脑脊髓炎中，对乳酸脱氢酶升高病毒（LDV）在基因易感性（C58/J）和抗性（C57BL/6J）小鼠中的复制动力学进行了研究。两种品系小鼠中LDV的外周复制模式（血浆浓度）相似。然而，中枢神经系统内病毒的浓度却明显不同。在不易感的C57BL/6J小鼠中，中枢神经系统内几乎未发现病毒或未发现病毒。在易感的C58/J小鼠的腰髓中，感染后5天LDV浓度开始升高，并在疾病临床前期持续升高。脊髓中LDV的浓度与运动神经元疾病的出现直接相关，但与炎症反应程度无关。
