Matlaga B F, Salthouse T N
J Biomed Mater Res. 1983 Jan;17(1):185-97. doi: 10.1002/jbm.820170115.
Transmission electron microscopy was used to study the ultrastructure of cells at the interface with an implanted biodegradable polymer, Polyglactin 910. Various stages of implantation were observed from 1 day to 63 days, when absorption of the polymer was essentially complete. Events occurring at the interface include initial adhesion of macrophages on the implant surface; phagocytosis of wound debris; and subsequent erosion, invasion, and phagocytosis of the polymer by macrophages and giant cells. A vascular perfusion technique for fixation of the polymer sites implanted in soft tissue is also described.
采用透射电子显微镜研究了与植入的可生物降解聚合物聚乙交酯丙交酯910界面处细胞的超微结构。观察了从1天到63天的不同植入阶段，此时聚合物的吸收基本完成。在界面处发生的事件包括巨噬细胞最初粘附在植入物表面；吞噬伤口碎片；随后巨噬细胞和巨细胞对聚合物的侵蚀、侵入和吞噬。还描述了一种用于固定植入软组织中聚合物部位的血管灌注技术。
