Godsland I F, Seed M, Simpson R, Broom G, Wynn V
J Clin Pathol. 1983 Feb;36(2):184-91. doi: 10.1136/jcp.36.2.184.
Six-hundred-and-eighty-two women volunteers from four ethnic groups--Black, Indian, Oriental and White took part in a study to assess differences in haematological indices between the groups. This study was part of a broad investigation into the metabolic effects of oral contraceptives. The effect of the oral contraceptive (OC) on haematological indices was analysed but not found to be significant. The haemoglobin concentrations were lower than normal laboratory reference values for White subjects in 12.5% of Indian, 16.5% of Black and 4.3% of Oriental control groups respectively. All the White control group were within the normal range. These findings were considered in relation to age, weight, pregnancies, smoking, alcohol consumption, nutritional status, and disorders of haemoglobin synthesis. A deficient iron intake accounted for the high incidence of low haemoglobin in the Indian group in whom low transferrin saturation and serum ferritin were observed. With the possible exception of inherited disorders of haemoglobin synthesis, none of the factors we considered could account for the low haemoglobins found in the Black group. Separate reference values for haematological indices in different ethnic populations are considered.
来自黑人、印度人、东方人和白人四个种族群体的682名女性志愿者参与了一项研究，以评估不同群体之间血液学指标的差异。这项研究是对口服避孕药代谢影响进行广泛调查的一部分。分析了口服避孕药（OC）对血液学指标的影响，但未发现其具有显著性。血红蛋白浓度分别低于印度对照组的12.5%、黑人对照组的16.5%和东方对照组的4.3%的白人受试者正常实验室参考值。所有白人对照组均在正常范围内。这些发现与年龄、体重、怀孕次数、吸烟、饮酒、营养状况以及血红蛋白合成障碍有关。铁摄入量不足导致印度组血红蛋白水平低的发生率较高，在该组中观察到转铁蛋白饱和度和血清铁蛋白水平较低。除了可能存在的血红蛋白合成遗传性疾病外，我们考虑的因素均无法解释黑人组中发现的低血红蛋白情况。文中还考虑了不同种族人群血液学指标的单独参考值。
