Takei H, Fredericks W R, London E D, Rapoport S I
J Neurochem. 1983 Mar;40(3):801-5. doi: 10.1111/j.1471-4159.1983.tb08050.x.
The cerebral metabolic rates for O2 and for glucose were measured in conscious, fasted male Fischer-344 rats at the ages of 3, 12, and 24 months, and cerebral blood flow was determined with 14C-iodoantipyrine. The metabolic rates for oxygen and glucose were obtained by multiplying blood flow by the O2 and glucose concentration differences, respectively, between blood in the femoral artery and in the superior sagittal sinus. Mean cerebral blood flow and the metabolic rates for oxygen and glucose did not differ significantly (p greater than 0.05) between 3 and 12 or between 12 and 24 months. Nor did the arteriovenous differences for O2 and for glucose change significantly with age. Because the superior sagittal sinus drains blood mainly from the cerebral cortex, the results indicate that average cerebral cortical oxidative metabolism, and the coupling ratios between the cerebral metabolic rate for oxygen and cerebral blood flow and between the cerebral metabolic rate for glucose and cerebral blood flow, do not change significantly with age in the Fischer-344 rat.
在清醒、禁食的3月龄、12月龄和24月龄雄性Fischer-344大鼠中测量脑氧代谢率和葡萄糖代谢率，并用14C-碘安替比林测定脑血流量。氧和葡萄糖的代谢率分别通过将血流量乘以股动脉血与上矢状窦血之间的氧和葡萄糖浓度差来获得。3月龄与12月龄之间以及12月龄与24月龄之间，平均脑血流量以及氧和葡萄糖的代谢率均无显著差异（p>0.05）。氧和葡萄糖的动静脉差异也不会随年龄而发生显著变化。由于上矢状窦主要引流大脑皮质的血液，结果表明，在Fischer-344大鼠中，平均大脑皮质氧化代谢以及脑氧代谢率与脑血流量之间、脑葡萄糖代谢率与脑血流量之间的耦合比不会随年龄而发生显著变化。
