Tomassi G, Olson J A
J Nutr. 1983 Mar;113(3):697-703. doi: 10.1093/jn/113.3.697.
After their liver reserves of vitamin A were enhanced to ca. 300 micrograms retinol/g by 5 large daily oral doses of retinyl palmitate, groups of rats (n = 6) were fed a vitamin A-free diet containing 10% corn oil, coconut oil or linseed oil, with or without vitamin E, for a 10-day period. The composition of polyunsaturated fatty acids (PUFA) in liver lipids reflected the dietary composition, with linoleate and linolenate being markedly increased in the livers of rats fed the corn and linseed oil diets, respectively, relative to those fed the coconut oil diet. In contrast, the predominant retinyl ester in the livers of rats on all three diets was retinyl palmitate (greater than 80%), with no diet-related change noted in the relatively small amounts of retinyl linoleate (1-4%) or of retinyl stearate and linolenate (6-11%) present. The depletion of vitamin A from the liver during the 10-day period was slight (less than or equal to 10%) and similar on all three diets. Thus, the ingestion of polyunsaturated fatty acids, with or without vitamin E, did not significantly influence either the mobilization rate or the ester composition of liver vitamin A reserves of rats in good vitamin A status. The relationship of these studies to previous investigations in which PUFA was shown to reduce liver and plasma concentrations of vitamin A is discussed.
通过每日口服5次大剂量的棕榈酸视黄酯，将大鼠肝脏中的维生素A储备提高到约300微克视黄醇/克后，将几组大鼠（n = 6）喂食不含维生素A但含有10%玉米油、椰子油或亚麻籽油的饮食，添加或不添加维生素E，持续10天。肝脏脂质中多不饱和脂肪酸（PUFA）的组成反映了饮食组成，相对于喂食椰子油饮食的大鼠，喂食玉米油和亚麻籽油饮食的大鼠肝脏中，亚油酸和亚麻酸分别显著增加。相比之下，三种饮食喂养的大鼠肝脏中，主要的视黄酯是棕榈酸视黄酯（大于80%），相对少量的亚油酸视黄酯（1-4%）或硬脂酸视黄酯和亚麻酸视黄酯（6-11%）的含量未观察到与饮食相关的变化。在10天期间，肝脏中维生素A的消耗轻微（小于或等于10%），且在所有三种饮食中相似。因此，无论是否添加维生素E，多不饱和脂肪酸的摄入对维生素A状态良好的大鼠肝脏维生素A储备的动员速率或酯组成均无显著影响。讨论了这些研究与先前研究的关系，先前研究表明PUFA可降低肝脏和血浆中维生素A的浓度。
