从RFM/Un小鼠细胞培养物中化学诱导的内源性逆转录病毒的分子克隆与分析。
Molecular cloning and analysis of the endogenous retrovirus chemically induced from RFM/Un mouse cell cultures.
作者信息
Liou R S, Boone L R, Kiggans J O, Yang D M, Wang T W, Tennant R W, Yang W K
出版信息
J Virol. 1983 Apr;46(1):288-92. doi: 10.1128/JVI.46.1.288-292.1983.
Abstract
We molecularly cloned and analyzed an N-tropic ecotropic retrovirus induced with iododeoxyuridine from RFM/Un mouse cell cultures. Based on the restriction map, the RFM/Un virus appears to be indistinguishable from other induced N-tropic retroviruses. A nucleotide sequence analysis of the long terminal repeat of an infectious clone revealed structural features characteristic of murine type C retrovirus long terminal repeats. The U3 region of the RFM/Un virus long terminal repeat, however, contained no short sequence duplication or insertion found in other murine leukemia virus isolates.
摘要
我们从RFM/Un小鼠细胞培养物中，通过碘脱氧尿苷诱导分子克隆并分析了一种N-嗜性亲嗜性逆转录病毒。根据限制酶切图谱，RFM/Un病毒似乎与其他诱导的N-嗜性逆转录病毒没有区别。对一个感染性克隆的长末端重复序列进行核苷酸序列分析，揭示了鼠C型逆转录病毒长末端重复序列的结构特征。然而，RFM/Un病毒长末端重复序列的U3区域，在其他鼠白血病病毒分离株中未发现短序列重复或插入。
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