莫洛尼氏肉瘤病毒72碱基对串联重复序列对SV40基因组的激活作用。
Activation of SV40 genome by 72-base pair tandem repeats of Moloney sarcoma virus.
作者信息
Levinson B, Khoury G, Vande Woude G, Gruss P
出版信息
Nature. 1982 Feb 18;295(5850):568-72. doi: 10.1038/295568a0.
DOI:10.1038/295568a0
PMID:6276775
Abstract
The simian virus 40 (SV40) 72-base pair (bp) tandem-repeated sequences have a crucial role as an activator element in viral gene expression. We replaced the SV40 72-bp repeat with a 72-bp repeat derived from the long terminal repeat (LTR) of cloned Moloney murine sarcoma virus (MSV) DNA. Although there is no detectable sequence homology to SV40, the MSV repeats can substitute functionally for the SV40 repeats and generate a viable virus in monkey kidney cells.
摘要
猿猴病毒40（SV40）72碱基对（bp）串联重复序列作为病毒基因表达中的激活元件发挥着关键作用。我们用源自克隆的莫洛尼鼠肉瘤病毒（MSV）DNA长末端重复序列（LTR）的72 bp重复序列取代了SV40 72 bp重复序列。尽管与SV40没有可检测到的序列同源性，但MSV重复序列在功能上可以替代SV40重复序列，并在猴肾细胞中产生有活力的病毒。
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