Yoshida T, Hiroki T, Arakawa K
Jpn Circ J. 1983 Feb;47(2):180-7. doi: 10.1253/jcj.47.180.
Platelet aggregation was studied in patients with angina pectoris in whom coronary sclerosis was found by arteriography. The subjects consisted of 20 patients with stable angina pectoris, 12 with unstable angina pectoris and 4 with variant form of angina pectoris. Fifteen healthy subjects served as controls. ADP- and collagen-induced platelet aggregations were estimated during resting conditions before and immediately after an exercise test. In patients with unstable angina pectoris, ADP-induced as well as collagen-induced platelet aggregations during resting conditions were significantly less than those in normal subjects. After exercise, however, they significantly increased. In stable angina pectoris, they did not differ from those in the control group and their responses to exercise were also not significant. In general, platelet aggregation during resting conditions was accelerated in relation to an increase in the number of coronary arteries involved. The results demonstrate that examination of platelet aggregation during resting conditions and following exercise aids in a more accurate evaluation of the types and the stages of patients with angina pectoris.
对经动脉造影发现有冠状动脉硬化的心绞痛患者的血小板聚集情况进行了研究。研究对象包括20例稳定型心绞痛患者、12例不稳定型心绞痛患者和4例变异型心绞痛患者。15名健康受试者作为对照。在运动试验前和运动试验后立即的静息状态下，评估了二磷酸腺苷（ADP）和胶原诱导的血小板聚集情况。在不稳定型心绞痛患者中，静息状态下ADP诱导的以及胶原诱导的血小板聚集明显低于正常受试者。然而，运动后，它们显著增加。在稳定型心绞痛患者中，它们与对照组无差异，且其对运动的反应也不显著。一般来说，静息状态下的血小板聚集随着受累冠状动脉数量的增加而加速。结果表明，检测静息状态下及运动后的血小板聚集有助于更准确地评估心绞痛患者的类型和阶段。
