Shea J J, Harell M
Laryngoscope. 1978 Sep;88(9 Pt 1):1477-84. doi: 10.1002/lary.1978.88.9.1477.
At present there are two methods of management of tinnitus: one old, by masking with a noise generator, and one new, by biofeedback. Neither of these methods is convenient and neither gets at the heart of the problem. A third method, using intravenous lidocaine as a test and oral carbamazepine therapy, was developed in the Pain Clinic of the Auckland General Hospital in New Zealand. This paper will report our brief experience with these drugs in the management of tinnitus and other similar disorders. Twenty-seven patients with intractable tinnitus had a significant reduction from a test dose of intravenous lidocaine and were treated with oral carbamazepine. Of this group 1 patient (4%) had complete relief, 21 patients (78%) had partial relief, and 5 patients (18%) had no relief. Complications were few and not serious, and either disappeared spontaneously or when the carbamazepine was stopped. One patient with palatal myoclonus, refractory to all other forms of treatment, had complete relief on a small dose of carbamazepine. It may be that palatal myoclonus, hemifacial spasm, and other such clonic convulsive disorders will be amenable to the same treatment.
目前,耳鸣的治疗方法有两种:一种是旧方法,即使用噪声发生器进行掩蔽;另一种是新方法,即生物反馈疗法。这两种方法都不方便,而且都没有触及问题的核心。第三种方法是在新西兰奥克兰总医院疼痛诊所研发的,即使用静脉注射利多卡因进行测试并采用口服卡马西平进行治疗。本文将报告我们使用这些药物治疗耳鸣及其他类似病症的简要经验。27名顽固性耳鸣患者静脉注射试验剂量的利多卡因后症状显著减轻,随后接受口服卡马西平治疗。在这组患者中,1例(4%)症状完全缓解,21例(78%)部分缓解,5例(18%)无缓解。并发症很少且不严重,要么自行消失,要么在停用卡马西平后消失。1例腭肌阵挛患者对所有其他治疗方法均无效,服用小剂量卡马西平后症状完全缓解。腭肌阵挛、半面痉挛及其他此类阵挛性惊厥性疾病可能同样适合这种治疗方法。