人体淋巴细胞中的砷与姐妹染色单体互换
Arsenic and SCE in human lymphocytes.
作者信息
Crossen P E
出版信息
Mutat Res. 1983 Mar;119(3):415-9. doi: 10.1016/0165-7992(83)90194-x.
The effects of tri- and penta-valent arsenic compounds on sister-chromatid exchange (SCE) in both G0 and 5-bromodeoxyuridine (BrdU) substituted chromosomes was investigated. ¿Of 4 donors whose lymphocytes were exposed to sodium arsenate for 2 cell cycles 1 showed an increase, 2 a decrease, and 1 neither an increase or decrease over baseline levels. Exposure to sodium arsenite produced a similar result with 2 of 4 donors showing a significant increase in SCE. G0 lymphocytes exposed to either sodium arsenate or sodium arsenite did not show increased SCE. These results indicate that although arsenic can induce SCEs in human lymphocytes, there is considerable variation in SCE response among individuals. Furthermore, the data suggest that the increased SCEs seen in patients exposed to arsenic may be due to the patient's condition and not arsenic exposure.
研究了三价和五价砷化合物对处于G0期以及用5-溴脱氧尿苷（BrdU）替代的染色体中姐妹染色单体交换（SCE）的影响。在4名供体中，其淋巴细胞暴露于砷酸钠2个细胞周期，1名供体的SCE增加，2名供体的SCE减少，1名供体的SCE与基线水平相比既未增加也未减少。暴露于亚砷酸钠产生了类似的结果，4名供体中有2名的SCE显著增加。暴露于砷酸钠或亚砷酸钠的G0期淋巴细胞未显示SCE增加。这些结果表明，虽然砷可诱导人类淋巴细胞中的SCE，但个体之间的SCE反应存在相当大的差异。此外，数据表明，在接触砷的患者中观察到的SCE增加可能是由于患者的病情，而非砷暴露。
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