未成熟造血细胞、T淋巴细胞和B淋巴细胞中的姐妹染色单体交换
Sister chromatid exchange in immature haemopoietic cells, T- and B-lymphocytes.
作者信息
Crossen P E, Godwin J M, Bodger M P
出版信息
Hum Genet. 1986 Jan;72(1):101-3. doi: 10.1007/BF00278828.
PMID:3484716
Abstract
T-lymphocytes, B-lymphocytes, and cells derived from human haemopoietic progenitor cells were analysed for their sister chromatid exchange (SCE) rate. T- and B-lymphocytes were separated and stimulated with phytohaemagglutinin (PHA) and Epstein Barr (EB) virus respectively, while the progenitor cells were cultured in the mixed colony assay. B-lymphocytes had a significantly lower SCE rate than either the T-lymphocytes or cells derived from progenitor cells.
摘要
对T淋巴细胞、B淋巴细胞以及源自人类造血祖细胞的细胞进行了姐妹染色单体交换（SCE）率分析。T淋巴细胞和B淋巴细胞被分离出来，分别用植物血凝素（PHA）和爱泼斯坦-巴尔（EB）病毒刺激，而祖细胞则在混合集落测定中进行培养。B淋巴细胞的SCE率明显低于T淋巴细胞或祖细胞衍生的细胞。
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