Beltramino C, Taleisnik S
Neuroendocrinology. 1983;36(1):53-8. doi: 10.1159/000123436.
The release of LH in ovariectomized, estrogen-primed rats exposed to male or female rats was studied. The concentration of LH in the serum was measured in blood samples obtained by an indwelling jugular cannula. A blood sample was taken at 12.00 h and then every hour up to 18.00 h following exposure to another rat on the opposite side of a double wire mesh screen. LH in the serum of control non-exposed rats showed a small rise between 16.00 and 18.00 h as compared to earlier values. Rats exposed to intact or castrated male rats exhibited an enhanced release. Exposure to ovariectomized rats failed to induce any change in the release of LH but exposure to ovariectomized, estrogen-primed rats produced a significant increase. No effect on LH release was seen in animals exposed to a female diestrous rat or to a pregnant rat. Rats exposed to an empty cage which had been soiled by housing a male rat for 3 days, showed an enhanced release of LH similar to those exposed to a cage containing the male rat, indicating the importance of olfactory stimuli in the response. Ovariectomized rats whose vomeronasal organs had been removed or whose accessory olfactory bulbs were lesioned, failed to show any effect on the release of LH when exposed to a male rat. It is concluded that olfactory stimuli arising from male or female rats are capable of modulating the release of LH in female rats and that perception of these stimuli involves the vomeronasal organ-accessory olfactory bulb system.
研究了去卵巢、经雌激素预处理的大鼠在接触雄性或雌性大鼠时促黄体生成素（LH）的释放情况。通过颈静脉留置套管采集血样，测定血清中LH的浓度。在通过双丝网筛与另一侧的另一只大鼠接触后，于12:00采集一份血样，然后每小时采集一次，直至18:00。与早期值相比，未接触的对照大鼠血清中的LH在16:00至18:00之间有小幅升高。接触完整或去势雄性大鼠的大鼠表现出促黄体生成素释放增强。接触去卵巢大鼠未能诱导LH释放发生任何变化，但接触去卵巢、经雌激素预处理的大鼠则导致显著增加。接触处于动情后期的雌性大鼠或怀孕大鼠的动物，LH释放未见影响。接触曾饲养过雄性大鼠3天的脏空笼的大鼠，其LH释放增强，类似于接触装有雄性大鼠笼子的大鼠，表明嗅觉刺激在该反应中的重要性。去除犁鼻器或损伤副嗅球的去卵巢大鼠，接触雄性大鼠时对LH释放未显示任何影响。得出的结论是，来自雄性或雌性大鼠的嗅觉刺激能够调节雌性大鼠LH的释放，并且对这些刺激的感知涉及犁鼻器 - 副嗅球系统。
