Milewicz A, Silber D, Kirschner M A
Obstet Gynecol. 1983 Apr;61(4):429-32.
The authors examined the effect of three months' treatment with spironolactone in 34 women with polycystic ovary syndrome. In all patients a significant decrease in hirsutism was noted as well as restoration of a regular although anovulatory menstrual pattern. Plasma luteinizing hormone and follicle-stimulating hormone levels remained unchanged after spironolactone treatment; however, prolactin levels were lowered in both women with normal and those with elevated basal levels. Plasma testosterone, androstenedione, and dehydroepiandrosterone sulfate levels were decreased after three months of therapy. No side effects were observed. Plasma electrolytes and liver function tests were normal during the entire time of treatment. This therapy is recommended as initial nontoxic but effective treatment for women with polycystic ovary syndrome who are hirsute and have menstrual disturbances.
作者研究了34名多囊卵巢综合征女性接受三个月螺内酯治疗的效果。所有患者的多毛症均显著减轻，月经周期恢复正常，尽管仍无排卵。螺内酯治疗后，血浆促黄体生成素和促卵泡生成素水平未发生变化；然而，基础水平正常和升高的女性的催乳素水平均有所降低。治疗三个月后，血浆睾酮、雄烯二酮和硫酸脱氢表雄酮水平均下降。未观察到副作用。治疗期间血浆电解质和肝功能检查均正常。对于多毛且有月经紊乱的多囊卵巢综合征女性，推荐将这种疗法作为初始无毒且有效的治疗方法。
