Vĕtr M, Sobek A
Department of Obstetrics and Gynecology, Medical Faculty, Palacký University, Olomouc, Czech Republic.
Acta Univ Palacki Olomuc Fac Med. 1993;135:55-7.
Thirty one women with hyperandrogenism, clinically divided into polycystic ovary syndrome (PCOS)--28 women and idiopathic hirsutism (I.H.)--3 women, were treated with low dose spironolactone (50 mg or 75 mg daily) for average five months. There was an excellent clinical response in 19 (61%), incomplete response in 8 (26%), no response in 5 women. Six of 18 patients with sterility became pregnant during the one year after treatment and delivered a healthy infant at term. Two patients dropped out of the trial because of intolerance of the therapy. Remarkable change of the menstrual pattern characterised as polymenorrhea was major side effect of the therapy. Other side effects were not problem. Spironolactone caused statistically significant reduction in testosterone, luteinizing hormone and prolactin values at the end of the treatment. Our results demonstrate that low-dose spironolactone is effective in the treatment of hyperandrogenism in women.
31名患有高雄激素血症的女性，临床上分为多囊卵巢综合征（PCOS）——28名女性和特发性多毛症（I.H.）——3名女性，接受低剂量螺内酯（每日50毫克或75毫克）治疗，平均治疗五个月。19名（61%）患者有良好的临床反应，8名（26%）患者反应不完全，5名女性无反应。18名不育患者中有6名在治疗后的一年内怀孕并足月产下健康婴儿。两名患者因不耐受治疗退出试验。以月经过频为特征的月经模式显著变化是该治疗的主要副作用。其他副作用不成问题。治疗结束时，螺内酯使睾酮、促黄体生成素和催乳素值在统计学上显著降低。我们的结果表明，低剂量螺内酯对治疗女性高雄激素血症有效。
