螺内酯治疗特发性多毛症和多囊卵巢综合征。
Spironolactone in the treatment of idiopathic hirsutism and the polycystic ovary syndrome.
作者信息
Evans D J, Burke C W
出版信息
J R Soc Med. 1986 Aug;79(8):451-3. doi: 10.1177/014107688607900806.
Abstract
Forty-eight hirsute women were treated with spironolactone 100 mg twice daily for 3 to 12 months. Both facial and body hirsuties improved by 30-40%, and there was a threefold reduction in frequency of local treatments such as waxing or shaving. Plasma testosterone fell by 30%, though the improvement in hirsuties grading did not correlate with the fall in plasma testosterone. Six subjects discontinued treatment because of lack of effect, and 4 because of menstrual disturbance. Spironolactone was equally effective in the treatment of idiopathic hirsutism and of the polycystic ovary syndrome.
摘要
48名多毛症女性患者接受了螺内酯治疗，剂量为每日100毫克，分两次服用，疗程为3至12个月。面部和身体多毛症状均改善了30%至40%，诸如脱毛或剃须等局部治疗的频率降低了三倍。血浆睾酮水平下降了30%，不过多毛症状分级的改善与血浆睾酮水平的下降并无关联。6名受试者因无效而停止治疗，4名因月经紊乱而停止治疗。螺内酯在治疗特发性多毛症和多囊卵巢综合征方面同样有效。
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本文引用的文献
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A novel use of spironolactone: treatment of hirsutism.
J Clin Endocrinol Metab. 1980 Sep;51(3):429-32. doi: 10.1210/jcem-51-3-429.
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Treatment of hirsutism with spironolactone.螺内酯治疗多毛症
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Therapeutic effects of spironolactone in polycystic ovary syndrome.螺内酯在多囊卵巢综合征中的治疗作用
Obstet Gynecol. 1983 Apr;61(4):429-32.
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The use of human skin fibroblasts to obtain potency estimates of drug binding to androgen receptors.利用人皮肤成纤维细胞来获取药物与雄激素受体结合的效价估计值。
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Antiandrogenic properties of spironolactone. Clinical trial in the management of female hirsutism.
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