Evans D J, Burke C W
J R Soc Med. 1986 Aug;79(8):451-3. doi: 10.1177/014107688607900806.
Forty-eight hirsute women were treated with spironolactone 100 mg twice daily for 3 to 12 months. Both facial and body hirsuties improved by 30-40%, and there was a threefold reduction in frequency of local treatments such as waxing or shaving. Plasma testosterone fell by 30%, though the improvement in hirsuties grading did not correlate with the fall in plasma testosterone. Six subjects discontinued treatment because of lack of effect, and 4 because of menstrual disturbance. Spironolactone was equally effective in the treatment of idiopathic hirsutism and of the polycystic ovary syndrome.
48名多毛症女性患者接受了螺内酯治疗，剂量为每日100毫克，分两次服用，疗程为3至12个月。面部和身体多毛症状均改善了30%至40%，诸如脱毛或剃须等局部治疗的频率降低了三倍。血浆睾酮水平下降了30%，不过多毛症状分级的改善与血浆睾酮水平的下降并无关联。6名受试者因无效而停止治疗，4名因月经紊乱而停止治疗。螺内酯在治疗特发性多毛症和多囊卵巢综合征方面同样有效。
