Delprete E, Scharrer E
Institute of Veterinary Physiology, University of Zürich, Switzerland.
Physiol Behav. 1992 May;51(5):951-6. doi: 10.1016/0031-9384(92)90076-e.
The effect of various doses of 2-deoxy-D-glucose (2-DG) on food intake in rats fed either a medium fat diet with a moderate carbohydrate content (MF-rats) or a carbohydrate-free high fat diet (HF-rats) was tested. Injections were given intraperitoneally either in the middle of the bright phase or 1 h after onset of the dark phase. During the light phase 2-DG induced a transient hyperphagia in both HF- and MF-rats, but the hyperphagia was somewhat less pronounced in HF-rats. During the dark phase 2-DG produced a hyperphagia in the MF-rats and a long-term hypophagia in the HF-rats. Since 2-DG elicited feeding in HF-rats during the light phase, the feeding response to 2-DG not only reflects hunger for carbohydrate as previously suggested but also seems to produce hunger for energy.
