盐酸茚达品对大鼠杏仁核点燃癫痫发作的影响：与苯妥英、地西泮、乙醇和丙咪嗪作用的比较。

Effects of indeloxazine HCl on kindled amygdaloid seizures in rats: comparison with the effects of phenytoin, diazepam, ethanol, and imipramine.

作者信息

Nakamura J, Anraku T, Shirouzu M, Iwashita Y, Nakazawa Y

机构信息

Department of Neuropsychiatry, Kurume University School of Medicine, Japan.

出版信息

Pharmacol Biochem Behav. 1993 Jun;45(2):445-50. doi: 10.1016/0091-3057(93)90263-s.

DOI:10.1016/0091-3057(93)90263-s

PMID:8327550

Abstract

The anticonvulsant effect of [(+/-)-2-[(inden-7-yloxy)methyl]morpholine (indeloxazine) HCl, a new cerebral activator, was investigated in rats against kindled seizures from the amygdala, an assumed model of secondarily generalized seizures in human. Indeloxazine (0.25-10 mg/kg, IP) dose-dependently depressed the kindled seizure and shortened the evoked amygdaloid afterdischarge. A high dose of indeloxazine (40 mg/kg, IP), however, induced generalized seizures. Comparison of the effects on the kindled seizures of indeloxazine to those of phenytoin, diazepam, ethanol, and imipramine revealed that the anticonvulsant actions of indeloxazine are similar to those of imipramine but not to those of phenytoin, ethanol, and diazepam. The results suggest that indeloxazine may exert its action through the monoaminergic system in the brain.

摘要

新型脑激活剂盐酸(±)-2-[(茚-7-基氧基)甲基]吗啉对大鼠杏仁核点燃性癫痫发作（一种假定的人类继发性全身性癫痫发作模型）的抗惊厥作用进行了研究。茚洛嗪（0.25 - 10毫克/千克，腹腔注射）剂量依赖性地抑制点燃性癫痫发作，并缩短诱发的杏仁核后放电。然而，高剂量的茚洛嗪（40毫克/千克，腹腔注射）会诱发全身性癫痫发作。将茚洛嗪对点燃性癫痫发作的作用与苯妥英、地西泮、乙醇和丙咪嗪的作用进行比较，结果显示茚洛嗪的抗惊厥作用与丙咪嗪相似，但与苯妥英、乙醇和地西泮不同。结果表明，茚洛嗪可能通过大脑中的单胺能系统发挥作用。