Unger S, Medici T C
Schweiz Med Wochenschr. 1983 Jan 22;113(3):104-6.
Duration of smoking career, number of cigarettes smoked and smoke inhalation pattern seem to have a bearing on the occurrence of tobacco-related lung diseases. The authors therefore determined the smoking pattern and especially the time relation between drawing on a cigarette and inhalation in smokers with and without tobacco-related lung diseases. Based on clinical and radiological findings as well as pulmonary function tests, 91 smokers (without lung disease, with small airway disease, with simple chronic bronchitis, with obstructive bronchitis, with bronchitis and predominantly emphysema and with lung cancer) were examined. Smoking and breathing pattern were recorded using a smoke flow machine and a strain-gauge belt while smoking a cigarette. The blood level of COHb was determined before and after smoking. Of the smoking characteristics peak pressure, peak flow, time from drawing to inhalation and COHb difference varied significantly among the different groups. Drawing-to-inhalation time was lowest in smokers with chronic bronchitis and predominantly emphysema, which differed significantly from the other groups. This characteristic may be the consequence or the cause of emphysema. Regarding the latter, smokers with emphysema may perhaps lack the acute airway response to smoke inhalation and thus be able to inhale the cigarette smoke directly.
吸烟生涯的时长、吸烟数量和吸入方式似乎与烟草相关肺部疾病的发生有关。因此,作者确定了吸烟方式,尤其是患有和未患有烟草相关肺部疾病的吸烟者在吸烟时吸烟动作与吸入之间的时间关系。基于临床和放射学检查结果以及肺功能测试,对91名吸烟者(无肺部疾病、患有小气道疾病、患有单纯性慢性支气管炎、患有阻塞性支气管炎、患有支气管炎且以肺气肿为主以及患有肺癌)进行了检查。在吸烟时,使用烟流仪和应变片式腰带记录吸烟和呼吸方式。测定吸烟前后的碳氧血红蛋白(COHb)血药浓度。在不同组中,吸烟特征中的峰值压力、峰值流量、从吸烟动作到吸入的时间以及COHb差异有显著不同。慢性支气管炎且以肺气肿为主的吸烟者的吸烟动作到吸入的时间最短,与其他组有显著差异。这一特征可能是肺气肿的结果或原因。就后者而言,患有肺气肿的吸烟者可能缺乏对吸入烟雾的急性气道反应,因此能够直接吸入香烟烟雾。