Bottazzi B, Polentarutti N, Acero R, Balsari A, Boraschi D, Ghezzi P, Salmona M, Mantovani A
Science. 1983 Apr 8;220(4593):210-2. doi: 10.1126/science.6828888.
Factor chemotactic for mononuclear phagocytes was found in supernatant fluids of cultured human and mouse tumor cells. In 11 mouse tumors there was a correlation observed between chemotactic activity and macrophage content of neoplastic tissues. Tumor-derived chemoattractants appear to participate in the regulation of tumor-associated macrophages.
在培养的人及小鼠肿瘤细胞的上清液中发现了单核吞噬细胞趋化因子。在11种小鼠肿瘤中，观察到趋化活性与肿瘤组织中巨噬细胞含量之间存在相关性。肿瘤衍生的趋化因子似乎参与了肿瘤相关巨噬细胞的调节。
