Bell G A, Fothergill J, Murphy J, Smith J A
Surg Gynecol Obstet. 1983 Mar;156(3):351-4.
In a prospective, randomized, double blind study of 123 patients undergoing elective colorectal surgery, 61 received intravenously erythromycin gluceptate, and 62 received intravenously metronidazole perioperatively together with tobramycin. Three dosages of each drug were given. Eight patients in each treatment group had wound infections. Of these, only three in each treatment group were severe enough to require antibiotic therapy and to cause prolongation of hospitalization. Antibiotic levels in the serums of patients, in skin samples and in intestinal walls showed that metronidazole was most frequently detected at satisfactory concentrations in serum and that skin and the intestinal wall did not contain any detectable antibiotic.
在一项对123例行择期结直肠手术患者的前瞻性、随机、双盲研究中，61例患者静脉注射葡庚糖酸红霉素，62例患者围手术期静脉注射甲硝唑并联合妥布霉素。每种药物均给予三种剂量。每个治疗组有8例患者发生伤口感染。其中，每个治疗组只有3例严重到需要抗生素治疗并导致住院时间延长。患者血清、皮肤样本和肠壁中的抗生素水平显示，甲硝唑在血清中最常被检测到且浓度令人满意，而皮肤和肠壁中未检测到任何抗生素。
