Daly D C, Maslar I A, Riddick D H
Am J Obstet Gynecol. 1983 Mar 15;145(6):679-83. doi: 10.1016/0002-9378(83)90573-2.
Immunoreactive prolactin (PRL) is produced from decidualized endometrium from the late luteal phase until the time of delivery. The induction of decidualization and the initiation of PRL production in the proliferative endometrium is dependent on progesterone (P) in vitro. This induction process is slowed by estradiol (E2). To determine whether this hormone dependency extends to term, decidua from labor and nonlabor term pregnancies was cultured in explant for response to P (100 ng/ml) and E2 (10 ng/ml) as evidenced by PRL production. On the first (n = 7) and eighth to ninth (n = 9) days of explant culture in nonlabor patients, P exposure resulted in significantly (p less than 0.01) more PRL production than in nonhormonal controls, and this increase was not inhibited by E2 at either time interval. In labor-exposed decidua, no significant response was noted to either P or E2 over 24 hours of culture. In all groups, tissue variability in PRL production was extensive. In nonlabor decidua, a significant interaction between basal PRL production and response to progesterone was noted (p less than 0.01). The role of P as an initiator and stimulator of PRL production extends to term; however, no clear effect of E2 is demonstrated. In labor-exposed decidua, this P response is eliminated. Whether this is a result of, or occurs prior to, labor is undetermined.
免疫反应性催乳素（PRL）由黄体期晚期直至分娩时的蜕膜化子宫内膜产生。在体外，增殖期子宫内膜的蜕膜化诱导及PRL产生的起始依赖于孕酮（P）。雌二醇（E2）会减缓这一诱导过程。为确定这种激素依赖性是否持续至足月，将足月分娩和未分娩孕妇的蜕膜进行外植体培养，以检测其对P（100 ng/ml）和E2（10 ng/ml）的反应，PRL产生情况可作为证据。在未分娩患者外植体培养的第1天（n = 7）以及第8至9天（n = 9），与无激素对照组相比，P处理导致PRL产生显著增多（p < 0.01），且在两个时间间隔内，这种增加均未被E2抑制。在分娩时暴露的蜕膜中，培养24小时期间对P或E2均未观察到显著反应。在所有组中，PRL产生的组织变异性都很大。在未分娩的蜕膜中，观察到基础PRL产生与对孕酮反应之间存在显著交互作用（p < 0.01）。P作为PRL产生起始剂和刺激剂的作用持续至足月；然而，未证实E2有明显作用。在分娩时暴露的蜕膜中，这种对P的反应消失。这是分娩的结果还是发生在分娩之前尚不确定。
