Yoder P R, Gibbs R S, Blanco J D, Castaneda Y S, St Clair P J
Am J Obstet Gynecol. 1983 Mar 15;145(6):695-701. doi: 10.1016/0002-9378(83)90575-6.
A study was made of the outcome for mothers and their neonates with both clinical and bacteriologic evidence of intra-amniotic infection at term. Samples of amniotic fluid from patients with intra-amniotic infection showed greater than 10(2) colony-forming units per milliliter of a high-virulence isolate, whereas samples from control patients showed no growth or low-virulence isolates only. Control patients were uninfected during labor and were matched on the basis of gestational age, interval from rupture of membranes to delivery, and mode of delivery. There were 67 matched pairs. The mean interval from diagnosis of intra-amniotic infection to delivery was 3.1 +/- 2.2 hours (+/- SD). Mothers with intra-amniotic infection had a significantly longer hospital stay and greater fever index after delivery than did control patients. Intrapartum bacteremia was documented in six of 50 (12%) women with intra-amniotic infection. The cesarean birth rate was 36%. There was one case of probable septic shock and one of postpartum hemorrhage among women with intra-amniotic infection. Infants in the intra-amniotic infection group had a significantly longer hospital stay than did the control infants. Among 59 infants for whom blood culture results were available, bacteremia was documented in five (8%) with intra-amniotic infection. Definite radiographic evidence of pneumonia was present in 4%; there were no cases of meningitis. There was one perinatal death in the intra-amniotic infection group. Overall, the maternal and perinatal outcome after intra-amniotic infection at term was excellent.
一项针对足月时具有羊膜腔内感染临床及细菌学证据的母亲及其新生儿结局的研究。羊膜腔内感染患者的羊水样本显示，每毫升有超过10(2)个集落形成单位的高毒力分离株，而对照组患者的样本无生长或仅有低毒力分离株。对照组患者在分娩期间未感染，根据孕周、胎膜破裂至分娩的间隔时间和分娩方式进行匹配。共有67对匹配组。从诊断羊膜腔内感染到分娩的平均间隔时间为3.1±2.2小时（±标准差）。羊膜腔内感染的母亲产后住院时间明显更长，发热指数也高于对照组患者。50名羊膜腔内感染的女性中有6名（12%）记录有产时菌血症。剖宫产率为36%。羊膜腔内感染的女性中有1例可能发生感染性休克，1例产后出血。羊膜腔内感染组的婴儿住院时间明显长于对照组婴儿。在59名有血培养结果的婴儿中，羊膜腔内感染的5名（8%）记录有菌血症。4%有明确的肺炎影像学证据；无脑膜炎病例。羊膜腔内感染组有1例围产期死亡。总体而言，足月时羊膜腔内感染后的母婴结局良好。
