Sommer A
Am J Ophthalmol. 1983 Mar;95(3):349-52. doi: 10.1016/s0002-9394(14)78304-7.
Retinoic acid 0.1% in arachis oil was applied to one eye and arachis oil alone to the other eye, of each of 19 patients with equivalent degrees of corneal xerophthalmia in the fellow eyes. Even with concomitant systemic vitamin A therapy, topical retinoic acid was associated with more rapid healing of corneal lesions in a substantial proportion of cases. Application of retinoic acid three times a day produced no significant side effects; application five times a day, however, resulted in moderate to severe conjunctival injection and increased corneal vascularization and scarring.
对19例双眼角膜干燥症程度相当的患者，每例患者一只眼使用含0.1%视黄酸的花生油，另一只眼仅使用花生油。即使同时进行全身维生素A治疗，在相当一部分病例中，局部使用视黄酸能使角膜病变愈合更快。每天使用视黄酸3次未产生明显副作用；然而，每天使用5次会导致中度至重度结膜充血，并增加角膜血管化和瘢痕形成。
