Van Horn D L, DeCarlo J D, Schutten W H, Hyndiuk R A
Arch Ophthalmol. 1981 Feb;99(2):317-21. doi: 10.1001/archopht.1981.03930010319021.
The purpose of this study was to evaluate the efficacy of topical retinoic acid (tretinoin) in the treatment of various stages of xerophthalmia caused by vitamin A deficiency. At the beginning of treatment, rabbits with similar disease in both eyes were given a normal diet and therapeutic doses (25,000 IU) of systemic vitamin A. One eye of each was treated with 0.1% retinoic acid in sesame oil one time per day. The other eye received sesame oil alone. Eyes with moderate disease (advanced keratinization and plaque formation) responded more quickly to topical retinoic acid (clear within three days) than did eyes treated with sesame oil (clear within seven days). No difference in time of response could be observed in corneas with milder or more severe disease (stromal infiltration and corneal vascularization).
本研究的目的是评估局部用维甲酸（维甲酸）治疗维生素A缺乏引起的各阶段干眼症的疗效。治疗开始时，双眼患有相似疾病的兔子给予正常饮食和治疗剂量（25,000国际单位）的全身性维生素A。每只兔子的一只眼睛每天用一次0.1%维甲酸芝麻油溶液治疗。另一只眼睛仅接受芝麻油。患有中度疾病（严重角化和斑块形成）的眼睛对局部用维甲酸的反应（三天内清除）比用芝麻油治疗的眼睛（七天内清除）更快。在患有较轻或较重疾病（基质浸润和角膜血管化）的角膜中，未观察到反应时间的差异。
