Ubels J L, Edelhauser H F, Foley K M, Liao J C, Gressel P
Curr Eye Res. 1985 Oct;4(10):1049-57. doi: 10.3109/02713688509003350.
In previous studies of topical application of retinoic acid to the eye, retinoic acid in an oil vehicle has been used. An all-trans-retinoic acid (Tretinoin, USP) formulation in a petrolatum-based ophthalmic ointment vehicle has now been developed which is chemically stable for at least one year. The ointment is effective at retinoic acid concentrations of 0.01-0.1% in reversing corneal keratinization in vitamin A-deficient, xerophthalmic rabbits. At 0.1% it also stimulates the healing rate of corneal epithelial wounds in rabbits and monkeys. Retinoic acid ointment may prove to be valuable clinically in the treatment of xerophthalmia, corneal epithelial erosions, and related ocular surface abnormalities.
在先前关于将视黄酸局部应用于眼部的研究中，使用的是油剂载体中的视黄酸。现已开发出一种基于凡士林的眼科软膏载体中的全反式视黄酸（维甲酸，美国药典）制剂，其化学稳定性至少为一年。该软膏在视黄酸浓度为0.01 - 0.1%时，可有效逆转维生素A缺乏的干眼症兔的角膜角化。在0.1%的浓度下，它还能刺激兔和猴角膜上皮伤口的愈合速度。视黄酸软膏在干眼症、角膜上皮糜烂及相关眼表异常的治疗中可能具有临床价值。
