Butler R W, Dickinson W A, Katholi C, Halsey J H
Ann Neurol. 1983 Feb;13(2):155-9. doi: 10.1002/ana.410130208.
Raw scores for cerebral blood flow (CBF), determined by xenon 133 inhalation, and for Wechsler Adult Intelligence Scale (WAIS) were measured in five groups of 12 subjects each: young normals, aged normals, and patients with cerebrovascular disease without dementia, dementia with cerebrovascular disease, and degenerative brain disease. Important differences were present in the raw data according to age and sex. When these were adjusted, a quadratic model revealed a highly significant (p less than 0.0001, r = 0.86) correlation between CBF and measured intelligence score. We interpret these findings to indicate that in dementing illnesses the WAIS raw score reflects the severity of the brain disorder, regardless of cause, and that CBF is reduced as a function of the severity rather than the cause of the abnormality.
通过吸入氙133测定的脑血流量（CBF）原始分数以及韦氏成人智力量表（WAIS）分数在五组受试者中进行了测量，每组12人，分别为年轻正常人、老年正常人、无痴呆的脑血管疾病患者、伴有脑血管疾病的痴呆患者以及退行性脑病患者。原始数据根据年龄和性别存在重要差异。在进行调整后，一个二次模型显示CBF与测得的智力分数之间存在高度显著的相关性（p小于0.0001，r = 0.86）。我们对这些发现的解读是，在痴呆性疾病中，WAIS原始分数反映了脑部疾病的严重程度，而不论其病因如何，并且CBF的降低是异常严重程度的函数，而非病因的函数。
