Eremeishvili M G, Bobrov V I, Beletskaia G T, Kuzovlev N F, Iakovlev V P
Antibiotiki. 1983 Jan;28(1):49-52.
The rate of sulfadimethoxine excretion from blood in patients with mechanical jaundice and cholangitis is the same as that in healthy persons. The renal excretion of the drug in such patients does not undergo any significant changes either. However, excretion of sulfadimethoxine with bile is impaired and the level of suppression of renal excretory function is proportional to the jaundice period. After decompression of the bile ducts renal excretory function in patients with mechanical jaundice is recovered.
机械性黄疸和胆管炎患者血液中磺胺二甲氧嘧啶的排泄率与健康人相同。此类患者中该药物的肾排泄也未发生任何显著变化。然而，磺胺二甲氧嘧啶随胆汁的排泄受损，且肾排泄功能的抑制程度与黄疸期成正比。胆管减压后，机械性黄疸患者的肾排泄功能得以恢复。
