Bobrov V I, Segel'man V S, Iakovlev V P
Antibiotiki. 1981 Dec;26(12):936-8.
Sulfadimethoxine excreted more rapidly in patients with chronic nephritis and the nephrotic syndrome than in subjects of the control group. Increased elimination of sulfadimethoxine from the blood of the persons with the kidney diseases was due to decreased reabsorption of the drug in the kidney tubules and increased rates of the drug biotransformation because of decreased binding by the blood serum proteins.
磺胺二甲氧嘧啶在慢性肾炎和肾病综合征患者体内的排泄速度比对照组受试者更快。肾病患者血液中磺胺二甲氧嘧啶消除增加是由于肾小管对该药物的重吸收减少，以及血清蛋白结合减少导致药物生物转化速率增加。
