乳酸脱氢酶同工酶1。缺血性心肌病的快速检测方法。
Lactate dehydrogenase isoenzyme 1. A rapid assay for ischemic myocardial disease.
作者信息
McCoy M T, Aguanno J J, Ritzmann S E
出版信息
Arch Intern Med. 1983 Mar;143(3):434-6. doi: 10.1001/archinte.143.3.434.
A rapid immunochemical method (Isomune-LD) for the determination of lactate dehydrogenase isoenzyme 1 (LD1) activity in serum was investigated, and the sensitivity and specificity of the assay were determined for the diagnosis of a myocardial infarction (MI). Multiple serum samples were obtained (on admission and at 12, 24, and 48 hours) from 85 patients (30 with proven MI and 55 without MI). The sensitivity of LD1 on admission and at 12, 24, and 48 hours was 43%, 84%, 96%, and 100%, respectively, and the specificity at these same time intervals was 95%, 100%, 97%, and 97%, respectively. Thus, the determination of LD1 by this rapid immunochemical method appears to allow a rapid laboratory evaluation of MI with a high degree of sensitivity and specificity.
研究了一种用于测定血清中乳酸脱氢酶同工酶1（LD1）活性的快速免疫化学方法（Isomune-LD），并确定了该检测方法对心肌梗死（MI）诊断的敏感性和特异性。从85例患者（30例经证实患有MI，55例未患MI）中获取多个血清样本（入院时以及12、24和48小时）。入院时以及12、24和48小时时LD1的敏感性分别为43%、84%、96%和100%，在相同时间间隔的特异性分别为95%、100%、97%和97%。因此，通过这种快速免疫化学方法测定LD1似乎可以对MI进行快速的实验室评估，且具有高度的敏感性和特异性。
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