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正常组织与恶性组织中组织叶酸的研究。

Investigations of tissue folates in normal and malignant tissues.

作者信息

Pheasant A E, Bates J, Blair J A, Nayyir-Mazhir R

出版信息

Br J Cancer. 1983 Mar;47(3):393-8. doi: 10.1038/bjc.1983.59.

DOI:10.1038/bjc.1983.59
PMID:6830689
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2011316/
Abstract

The folates present in liver, gut and tumour tissue were examined before and after autolysis. Before autolysis 10-formylfolate tetraglutamate (10-CHOFA(glu)4), 5-methyltetrahydrofolate triglutamate (5-CH3THF(glu)3) and possibly tetrahydrofolate polyglutamate(s) (THF(glu)n) were detected. Liver contained all 3 species whereas no 5-CH3THF(glu)3 was present in the tumours; gut showed an intermediate situation. After autolysis the predominant monoglutamates formed were 5-CH3THF in the liver, 10-formylfolates in the gut and possibly tetrahydrofolate (THF) in the tumour extracts. These differences illustrate changes in tissue folates with the proliferation rate of the tissue and suggest an explanation for the methionine auxotrophy of Walker 256 carcinosarcoma cells.

摘要

对肝脏、肠道和肿瘤组织中的叶酸在自溶前后进行了检测。自溶前检测到了10-甲酰基叶酸四谷氨酸（10-CHOFA(glu)4）、5-甲基四氢叶酸三谷氨酸（5-CH3THF(glu)3）以及可能的四氢叶酸多谷氨酸（THF(glu)n）。肝脏中含有所有这三种物质，而肿瘤组织中不存在5-CH3THF(glu)3；肠道呈现出中间状态。自溶后，肝脏中形成的主要单谷氨酸是5-CH3THF，肠道中是10-甲酰基叶酸，肿瘤提取物中可能是四氢叶酸（THF）。这些差异说明了组织叶酸随组织增殖率的变化，并为沃克256癌肉瘤细胞的甲硫氨酸营养缺陷提供了一种解释。

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本文引用的文献

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The reaction of tetrahydropteroylglutamic acid and related hydropteridines with formaldehyde.四氢蝶酰谷氨酸及相关蝶啶与甲醛的反应
Biochem J. 1959 Aug;72(4):707-15. doi: 10.1042/bj0720707.
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Distribution of pteroylglutamates in rat liver during regeneration after partial hepatectomy.部分肝切除术后大鼠肝脏再生过程中蝶酰谷氨酸的分布
Biochem J. 1980 May 15;188(2):553-6. doi: 10.1042/bj1880553.
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The identification of the folate conjugates found in rat liver 48 h after the administration of radioactively labelled folate tracers.放射性标记叶酸示踪剂给药48小时后在大鼠肝脏中发现的叶酸共轭物的鉴定。
Biochem J. 1980 Jan 15;186(1):235-42. doi: 10.1042/bj1860235.
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Identification of folate binding protein of mitochondria as dimethylglycine dehydrogenase.线粒体叶酸结合蛋白鉴定为二甲基甘氨酸脱氢酶。
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4484-8. doi: 10.1073/pnas.77.8.4484.
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Multiple antigenic specificities within primary 3-methylcholanthrene-induced rat sarcomas and metastases.原发性3-甲基胆蒽诱导的大鼠肉瘤和转移瘤中的多种抗原特异性。
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A convenient method for the preparation of dl-5-methyltetrahydrofolic acid (dl-5-methyl-5,6,7,8-tetrahydropteroyl-L-monoglutamic acid).一种制备dl-5-甲基四氢叶酸（dl-5-甲基-5,6,7,8-四氢蝶酰-L-单谷氨酸）的简便方法。
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Reciprocal changes in the levels of functionally related folate enzymes during the culture cycle in human fibroblasts.在人成纤维细胞培养周期中，功能相关叶酸酶水平的相互变化。
Biochem Biophys Res Commun. 1973 Oct 15;54(4):1627-33. doi: 10.1016/0006-291x(73)91173-x.
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J Biol Chem. 1972 Apr 25;247(8):2266-71.
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Biochem Biophys Res Commun. 1972 Apr 14;47(1):35-43. doi: 10.1016/s0006-291x(72)80006-8.
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The effect of replacement of methionine by homocystine on survival of malignant and normal adult mammalian cells in culture.同型胱氨酸替代甲硫氨酸对培养的成年哺乳动物恶性及正常细胞存活的影响。
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1133-6. doi: 10.1073/pnas.71.4.1133.

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