同型胱氨酸替代甲硫氨酸对培养的成年哺乳动物恶性及正常细胞存活的影响。
The effect of replacement of methionine by homocystine on survival of malignant and normal adult mammalian cells in culture.
作者信息
Halpern B C, Clark B R, Hardy D N, Halpern R M, Smith R A
出版信息
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1133-6. doi: 10.1073/pnas.71.4.1133.
Abstract
In tissue cultures of normal adult and malignant mammalian cells, homocystine has been substituted for methionine in a medium rich in folic acid and cyanocobalamin. Normal adult cells thrive. Three highly malignant cell types from three different species, including man, die.
摘要
在正常成年哺乳动物细胞和恶性哺乳动物细胞的组织培养中，在富含叶酸和氰钴胺素的培养基中，同型胱氨酸已被用来替代蛋氨酸。正常成年细胞生长旺盛。来自包括人类在内的三个不同物种的三种高度恶性细胞类型死亡。
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