[Study of the permeability of bilayer lipid membranes by the Monte-Carlo method].

Results are presented of computer modelling of small molecules transfer through the double lipid layer of the membrane. The problem is considered on the basis of "kink" theory. Dependence of the permeability coefficient P on temperature T and area A per one lipid chain on the interface surface was studied. It has been shown that with T and (or) A decrease the value P decreases. The P values calculated, as well as probabilities of "kinks" and gauche-isomers for the chains in liquid--crystal bilayer well agree with the experimental data. It has been shown that the admixture molecules introduced between the bilayer lipid chains decrease its permeability.